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About the project

This project will establish a multidisciplinary collaboration between the existing teams at the Quadram Institute, University of East Anglia and the Centre for Mathematical Biology at the University of Oxford thus bringing together international leading scientists with complementary expertise in mathematical and computational biology and in the biology of the gastrointestinal tract.

It will aim to understand the tight coordination between villi and crypts during the continuous renewal of the epithelium lining the small intestine and how this equilibrium is recovered after perturbations. It will combine theoretical approaches with experimental work, in a predict-test-refine-predict cycle, to identify the mechanisms that regulate homeostasis in the healthy intestinal epithelium and those that restore equilibrium after disruption.